TOPLINE:

In patients with primary hypothyroidism receiving a stable dose of levothyroxine , thyroid-dependent quality of life (QOL) was driven by psychological factors, including somatosensory amplification and depression , and body mass index (BMI), rather than by thyroid biomarkers.

METHODOLOGY:

Levothyroxine monotherapy to normalise serum thyrotropin (TSH) is the standard treatment for primary hypothyroidism and greatly improves symptoms and life expectancy, yet at least 10%-15% of patients still experience persistent symptoms and reduced QOL despite having normal TSH levels.

Researchers conducted a cross-sectional study (August 2021 to 2022) to examine predictors of QOL in 157 adults (mean age, 49.5 years) with primary hypothyroidism for more than 2 years who were free of maj

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