TOPLINE:

Administration of dexmedetomidine in patients undergoing cardiac surgery reduced the incidence of postoperative delirium by 38% but was associated with an increased risk for hypotension.

METHODOLOGY:

Researchers conducted a systematic review and meta-analysis of 18 randomized controlled trials involving 3904 patients undergoing any type of cardiac surgery.

They compared the use of dexmedetomidine with the use of propofol or normal saline as a control in patients in the intensive care unit, with administration either intraoperatively or postoperatively.

The primary outcome was the incidence of postoperative delirium, assessed using the Confusion Assessment Method scale or other scales, in an intention-to-treat analysis.

The secondary outcomes included the duration of delirium

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