The Michigan Department of Health and Human Services (MDHHS) has issued a warning about a significant rise in emergency health incidents related to the recreational use of nitrous oxide, commonly known as “laughing gas,” across the state.

According to a June 4 news release from the MDHHS, between 2019 and 2024, calls to the Michigan Poison and Drug Information Center (MiPDC) regarding adverse effects from nitrous oxide use increased by 533%.

Emergency medical service responses related to nitrous oxide misuse rose by 553%, and emergency department visits surged by 757% from 2019 to 2023.

“The drug landscape is constantly changing and the increases in nitrous oxide misuse are concerning, given the widespread availability of the product and the increase in multiple substance use,” said Dr.

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