Denise and Cliff Castellano are celebrating 35 years of marriage this summer.

“She is my best friend,” Cliff Castellano, of Wallingford, said.

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About three years ago, Cliff noticed something was off about his wife, specifically at work.

“I noticed things starting to slip with dates and things like that that normally she was always 100% on top of,” Cliff said.

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Denise was diagnosed with mild Alzheimer’s and is the first patient at Hartford HealthCare’s Ayer Neuroscience Institute to be treated with a new FDA-approved drug called Donanemab.

“So the way the drug works it is a manufactured antibody that tags

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