TOPLINE:

The LoDoCo2 trial found a reduced cardiovascular risk with low-dose colchicine in patients with chronic coronary disease. In this substudy, attenuation of pericoronary adipose tissue did not differ between patients receiving low-dose colchicine and those receiving placebo; however, people taking colchicine had a higher volume of dense calcified plaque, indicating improved plaque stability.

METHODOLOGY:

Elevated attenuation of pericoronary adipose tissue and a high burden of noncalcified plaque have been linked to adverse coronary outcomes caused by plaque rupture and instability; statins mitigate these risks by promoting plaque calcification.

This cross-sectional substudy of the LoDoCo2 trial investigated if treatment with low-dose colchicine would attenuate coronary inflammat

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