Preseason football is finally over. The 2025 NFL regular season is finally at our doorsteps, with less than two weeks to go before kickoff officially begins. Each new season brings a renewed energy among all 32 NFL teams’ fanbases.

No one circles the wagons like Bills Mafia, and few teams find as favorable FanDuel Sportsbook odds in 2025 as the Buffalo Bills. With reigning NFL MVP Josh Allen at the helm, Buffalo will look to win the AFC East for a sixth consecutive time — further extending their current franchise record (5 division titles in a row). The meter’s running, and head coach Sean McDermott’s looking for more.

Let’s dive into some of the odds for popular betting categories at FanDuel Sportsbook in case you want to wager some hard-earned cash!

Bills win totals

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