The Buffalo Bills are heavy favorites in 2025 — that is, heavy favorites to win a lot, which of course includes the AFC East, and extend their current record five-straight division titles dating back to the 2024 NFL season. Since quarterback Josh Allen took full command, the franchise has been among the best in the league — in fact the Bills have made the playoffs every year with Allen other than his rookie season.

Will the rest of the AFC East challenge Buffalo and its first-place finisher schedule (based off 2024 season) for 2025? For now, it’s wise to take a wait-and-see approach. Heading into Week 1 perceptions and odds favor the Bills in each matchup of the season. Current odds at FanDuel Sportsbook see the Bills with very favorable odds of winning the AFC East in 2025.

AFC East win

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