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Hollywood star George Clooney , 64, skipped a string of major appearances at the Venice Film Festival, as he battles a sinus infection, his rep confirmed with Fox News Digital.

"George has been diagnosed with a sinus infection and is under doctor’s orders to cut back all activities today," Clooney’s rep said Thursday.

Clooney was a no-show at a press junket for "Jay Kelly," his latest film directed by Noah Baumbach, and missed a high-profile dinner with co-stars Adam Sandler and Laura Dern.

GEORGE CLOONEY MAKES DRAMATIC RETURN TO HIS SIGNATURE SILVER FOX STATUS AT 2025 TONY AWARDS

The "Ocean's Eleven" actor was reportedly seen boarding a water taxi at approximately 4 p.m. local time Wednesday as he quietly left the Hot

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