Key takeaways:

IOP lowering is effective for the treatment of normal-tension glaucoma.

Normal-tension glaucoma is easy to miss, so pay closer attention to optic nerve and OCT imaging during certain eye exams.

Normal-tension glaucoma is typically defined as open-angle glaucoma with IOP that is 21 mm Hg or less. Despite the seemingly “normal” IOP, there is progressive damage to the optic nerve.

In many Asian countries, normal-tension glaucoma (NTG) is the dominant form of glaucoma, accounting for 70% of all POAG cases in China (Zhao et al.), 77% in Korea (Kim et al.) and 92% in Japan (Iwase et al.). But even among white, Black and Hispanic populations in the U.S., NTG is not uncommon, accounting for approximately 25% to 50% of all open-angle glaucoma (OAG) cases. Myopes are more likely

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