Renee Graziano is telling people to back off Serena Williams and any other star who's used weight-loss drugs ... telling the haters to go see their doctors if they're jealous of others.

We caught up with "Mob Wives" star at the "Run" movie premiere at AMC Magic Johnson theater in Harlem earlier this week ... and, we talked to her about dropping nearly 60 pounds with Mounjaro -- a drug originally meant for diabetic patients, much like Ozempic, which many rich and famous folks are using to lose weight.

Graziano's very clear about how much real estate her detractors are taking up in her head ... and, the answer is absolutely none. Gallery Launch Gallery

She says she looks great and even feels Mounjaro is slowing down her aging to a crawl ... and, she's simply not going to apol

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