The NFL preseason is in the books, and now all the focus turns to the Week 1 NFL schedule, which is now less than one week away from kicking off. It's another strong opening slate that begins with Cowboys vs. Eagles in the 2025 NFL Kickoff Game on Thursday, followed by Chiefs vs. Chargers in Brazil on Friday. Thirteen games are on the Sunday schedule, with Vikings vs. Bears wrapping it up on Monday. NFL bettors are often targeting spreads, totals and money-line NFL picks. Some key Week 1 NFL odds include the Eagles at -7.5 against the Cowboys, which has moved a half point since the Micah Parsons trade, and the Vikings at -1.5 against Chicago. The Bills, meanwhile, are -1.5 against the Ravens in a Sunday Night Football showdown between AFC contenders.

A set of exact Week 1 NFL score predic

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