Ben Shelton and Frances Tiafoe both crashed out in the third round of the US Open on a bleak day for a host nation without a men's Grand Slam champion in over 20 years.

Sixth seed Shelton, a 2023 semi-finalist and recent Toronto champion, saw his bid derailed by a shoulder injury that forced him to retire against Frenchman Adrian Mannarino.

Tiafoe, who had reached the semi-finals in New York twice in the past three years, followed Shelton through the exit door shortly after on Friday as he lost in straight sets to German qualifier Jan-Lennard Struff.

Shelton led Mannarino by two sets to one before hurting his shoulder at the start of the fourth set.

He attempted to play through the pain but eventually threw in the towel after the 77th-ranked Mannarino took the match to a deciding set.

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