Penn State will kick off its most anticipated season in decades when it hosts Nevada on Saturday at Beaver Stadium.

The Nittany Lions will open 2025 as the No. 2-ranked team in the preseason AP poll, trailing only top-ranked Texas by five points and two first-place votes.

PSU went 13-3 and qualified for the College Football Playoff for the first time. It returns starting QB Drew Allar and starting running backs Kaytron Allen and Nicholas Singleton, but lost most of its best pass catchers, including tight end Tyler Warren.

Here’s how to bet PSU’s season opener vs Nevada.

Penn State vs Nevada predictions and best bets

Penn State -24.5 1H spread: (-130 odds at FanDuel Sportsbook)

Nevada +43.5: (-115 odds at BetMGM Sportsbook)

Under 55.5 points: (-110 odds at bet365 Sportsbook)

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