Carlos Alcaraz and Novak Djokovic can set up a heavyweight clash at the US Open on Tuesday, while Aryna Sabalenka aims to take another stride towards defending her title.
Spanish second seed Alcaraz is the only man yet to concede a set at the tournament as he goes in search of a second US Open title and sixth Grand Slam.
The 22-year-old takes on Czech 20th seed Jiri Lehecka, who is in the quarter-finals of a major for only the second time.
"Against a player like Carlos you need to bring your best," said Lehecka. "He's one of the two biggest challenges right now in tennis."
Lehecka defeated Alcaraz in Doha in their only meeting on hard courts, with the Spaniard getting the better of the Czech in another three-set tussle at Queen's in June.
The winner of that match will face either 24-t