The 2025 NFL Kickoff Game will feature two bitter rivals facing off when the Philadelphia Eagles host the Dallas Cowboys on Thursday. The Eagles enter the 2025 NFL season as the defending Super Bowl champions, while the Cowboys will try to reach the postseason after a disappointing 7-10 campaign in 2024. Thursday's matchup marks the first Week 1 meeting between these NFC East rivals since 2000.

Kickoff is set for 8:20 p.m. ET from Lincoln Financial Field in Philadelphia. The Eagles are favored by 8 points in the latest Eagles vs. Cowboys odds at DraftKings Sportsbook, while the over/under for total points scored is 47.5. Before making any Cowboys vs. Eagles picks, make sure you check out the NFL picks from the SportsLine Projection Model.

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