The NFL leaves America, though not the Americas, when it heads to the biggest city in the Western Hemisphere, Sao Paulo, Brazil, for a Friday night special between the Kansas City Chiefs and Los Angeles Chargers .

The Week 1 game, which will be streamed on YouTube , the second of the 2025 season, pits the defending AFC champions against a Chargers team coming off a solid 11-6 playoff season, as this is a game between the top two finishers in the AFC West last season.

Kansas City comes in as a slight favorite in a game where technically Los Angeles is the home team. That mostly means it loses a game in Los Angeles to travel four times zones halfway across the world for a "home game."

What channel is the NFL game on tonight?

Kansas City Chiefs vs. Los Angeles Chargers game will

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