SEC rivals meet in Week 2 of the college football season as the Kentucky Wildcats host the No. 20 Ole Miss Rebels . These teams met in Week 5 last season, when Kentucky's defense held off Lane Kiffin's offense for a 20-17 road win. Both teams won their 2025 season openers, with Ole Miss dominating Georgia State, 63-7, and Kentucky holding off Toledo, 24-16.

Kickoff from Kroger Field in Lexington is set for 3:30 p.m. ET. The Rebels are 8.5-point favorites in the latest Ole Miss vs. Kentucky odds from SportsLine consensus, while the over/under for total points scored is set at 50.5. Before making any Kentucky vs. Ole Miss picks, make sure you check out the picks from the SportsLine projection model. New users at bet365 can get $300 in bonus bets instantly with the latest bet365 bon

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