The Seattle Seahawks open their first week of the 2025 NFL regular season with a home game against the San Francisco 49ers on Sunday, Sept. 7.

Keeping up with a practice that Seattle coach Mike Macdonald started last season, the Seahawks named their captains for the Week 1 matchup against the 49ers, Seahawks.com reported. They are quarterback Sam Darnold, defensive end Leonard Williams and fullback Brady Russell.

It'll be the 53rd regular-season matchup between the two teams, with Seattle holding a 30-22 advantage, according to Pro Football Reference .

Here's what you need to know about where to watch the Seahawks take on the 49ers, the Seahawks' 2025 schedule and more.

What time does the Seattle Seahawks vs San Francisco 49ers game start on Sunday, Sept. 7, 2025?

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