SAO PAULO -- The Kansas City Chiefs experienced their first significant injury on just the third snap of the season.

Xavier Worthy , the Chiefs' fastest receiver, suffered a right shoulder injury while running a crossing route on the team's first third-down play. Instead of finishing his route, Worthy collided with tight end Travis Kelce , who was running a crossing route in the opposite direction.

The play ended with quarterback Patrick Mahomes throwing an incompletion because Worthy, a second-year player, fell to the turf.

A few minutes later, after the Chiefs punted the ball to the Chargers, Worthy walked back to the locker room with a towel over his bowed head. Before halftime, the Chiefs ruled Worthy out for the remainder of the game.

The Chiefs entered Friday's season open

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