The 15th-ranked Michigan Wolverines battle the 18th-ranked Oklahoma Sooners in a Big Ten-SEC Week 2 matchup on Saturday. Both teams won their season openers, with Michigan earning a 34-17 win over New Mexico, while Oklahoma defeated Illinois State 35-3. The Wolverines, who finished 8-5 overall in 2024, were 1-3 on the road last year. The Sooners, who were 6-7 last season, were 5-2 on their home field.

Kickoff is set for 7:30 p.m. ET at Gaylor Family Oklahoma Memorial Stadium in Norman, Okla. The Sooners are 5.5-point favorites in the latest Oklahoma vs. Michigan odds, while the over/under for total points scored is 44, down from opening at 53.5. Before making any Michigan vs. Oklahoma picks, check out the college football predictions from the SportsLine Projection Model .

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