The Pittsburgh Pirates (64-81) and the Baltimore Orioles (67-77) play the second game of a 3-game series Wednesday. First pitch from Oriole Park at Camden Yards is scheduled for 6:35 p.m. ET. Let's analyze BetMGM Sportsbook's MLB odds around the Pirates vs. Orioles odds and make our expert MLB picks and predictions for the best bets.

Season series: Orioles lead 1-0

The Orioles beat the Pirates 3-2 in 11 innings in Tuesday's series opener, cashing as -143 home favorites with the Under (7.5) hitting. C Samuel Basallo hit a walk-off RBI single in the 11th inning with the bases loaded.

Pirates LF Tommy Pham hit a solo shot in the ninth to tie the game and force extras. Pittsburgh has lost 4 games in a row.

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