The Week 2 NFL lines have something for every kind of NFL bettor. There are four games with a spread of less than a field goal, including Patriots vs. Dolphins (-1.5), Broncos vs. Colts (+2.5) and Chiefs vs. Eagles (-1). There is also a contest with the first double-digit spread of the 2025 NFL season as Baltimore is favored by 11.5 points over Cleveland, per the latest Week 2 NFL odds. There is even a doubleheader on Monday Night Football with Buccaneers vs. Texans (-2.5) followed by Chargers vs. Raiders (+3.5).

What can one take away from the opening slate of games to help with Week 2 NFL betting? One week doesn't provide enough data to draw meaningful trends or tendencies, which only makes NFL predictions all the more difficult. So, before locking in any Week 2 NFL

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