One of the biggest rematches in the 2025 NFL season takes place in Week 2 as the Kansas City Chiefs host the Philadelphia Eagles . This is the first time these teams have season each other since Super Bowl 58, which the Eagles won 40-22. Philadelphia is flying high heading into Week 2 after winning its 2025 season opener, 24-20, against the Dallas Cowboys. Meanwhile, the Chiefs are looking to get back to their winning ways after falling to the Los Angeles Chargers, 27-21, in the NFL Sao Paulo Game on Friday.

Kickoff from Arrowhead Stadium is set for 4:25 p.m. ET. Philadelphia is a 1-point favorite in the latest Eagles vs. Chiefs odds from SportsLine consensus, while the over/under for total points scored is set at 47. The Eagles are -115 money line favorites (risk $115 to win $100), w

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