Kyler Murray threw for 220 yards and a touchdown and the Arizona Cardinals' defense took care of business until the fourth quarter in a 27-22 home-opening victory against the Carolina Panthers on Sunday in Glendale, Ariz.

Arizona linebacker Zaven Collins returned a fumble for a touchdown. The Panthers didn't reach the end zone until almost 43 minutes into the game, yet the Cardinals needed a late defensive stand to hold on.

Murray finished 17-for-25 passing with an interception.

Carolina quarterback Bryce Young, who committed turnovers on the Panthers' first two possessions, ended up 35-for-55 for a career-high 328 yards in the air with three touchdown throws and an interception. Hunter Renfrow caught two TD passes.

Arizona (2-0) carried a 20-3 lead into halftime despite only a 145-112

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