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Two teenagers have been charged, including one with murder, over the fatal stabbing of a man walking along a road in northern NSW.

The 35-year-old victim found with stab wounds on the Gwydir Hwy near Hay St in Waterview about 1am on Wednesday.

He was treated by paramedics but died at the scene.

Police say the attack was targeted with detectives finding a knife, a metal pole and the handle of an axe at the scene.

Following investigations detectives executed a search warrant at a home on Bent St in South Grafton about 2.40pm on Wednesday.

A 17-year-old boy was arrested at the home and charged with murder DV.

Later that day about 7p

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