Mike's Week 4 college football betting picks against the spread for Thursday, September 18, and Friday, September 19, 2025. Free CFB betting predictions, odds analysis, and ATS picks from RotoBaller.

Week 3 of the 2025 college football season brought some more upsets. Who would have guessed that Clemson, Notre Dame, and Florida would be a combined 2-6 through three weeks?

No FCS teams collected scalps this week, and time is running out for them to collect more. On the bright side, Akron finally scored points. Long Island, Bryant, Tarleton, and Austin Peay are still the FCS teams to beat FBS foes. New Hampshire got really close to joining that list against Ball State. Indiana State did not. The Sycamores only had 77 total yards against Indiana.

We have another loaded weekend with 62 tota

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