The Miami Dolphins are massive underdogs as they seek their first win in Buffalo since 2016 while also trying to avoid losing three times in a 12-day span to open the 2025 regular season on Thursday night.

The Bills are already alone atop the AFC East standings at 2-0, but do have significant injury concerns on defense while playing on a short week.

ODDS AND TRENDS

Buffalo is a consensus 12.0-point favorite, ranging from 11.5 points at books including BetRivers and BetMGM to 12.5 points at DraftKings, among others. BetRivers reported 84 percent of the spread-line money has backed the Bills, while their -1000 moneyline has also drawn 97 percent of the money.

The Dolphins have failed to cover the spread in six of their past eight games, while the Bills have covered the spread in four con

See Full Page