SANTA CLARA, Calif. (AP) — When Kyler Murray is at his best, he can be a nightmare for the opposition with his ability to break off long runs, avoid sacks and extend plays doing damage to even the best NFL defenses.

The San Francisco 49ers saw that first-hand last season when Murray's dual-threat ability helped the Arizona Cardinals sweep the season series. Now as the Niners (2-0) get their first chance against Murray and the Cardinals (2-0) this season in the home opener on Sunday, controlling Murray will be job one.

“Our ‘what it takes meeting’ was very much about him and what he brings to the table and how we need to rush him, how we need to take care of the QB run game,” star defensive end Nick Bosa said. “I’m excited about the plan this week."

Murray shined last season against the

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