The Rice Owls (2-1) and the Charlotte 49ers (1-2) square off in an American Conference showdown on Thursday. The Owls beat Prairie View A&M 38-17 back on Sept. 13. Meanwhile, Charlotte snapped its two-game losing streak and got win No. 1 on the year. In Week 3, the 49ers outmatched Monmouth, winning 42-35.

Kickoff from Jerry Richardson Stadium in Charlotte, North Carolina, is set for 7:30 p.m. ET. The Owls are 2.5-point favorites, according to the latest Rice vs. Charlotte odds, while the over/under for total points scored is 42.5, down three from the opening line. The Owls are -128 money line favorites (risk $128 to win $100), while the 49ers are +108 underdogs. Before making any Charlotte vs. Rice picks, make sure you check out the college football picks and betting advice from the Sp

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