No double-digit favorites have lost yet in the 2025 NFL season, but Week 3 did bring perhaps the biggest upset of the year thus far as the Packers fell to the Browns as 7.5-point favorites. That was one of the first big hits for NFL survivor players, and now those who remain are formulating their Week 4 NFL survivor picks with the options beginning to dwindle a bit. The Bills are the biggest favorites on the board (-16.5) this week against the Saints, though many survivor pool players already used Buffalo as big favorites against the Dolphins in Week 3.

The latest Week 4 NFL odds show six other games with a Week 4 NFL spread of 5.5 points or more, including Browns vs. Lions (-9.5), Patriots (-5.5) vs. Panthers, Titans vs. Texans (-7), Chargers vs. Giants (+6.5), Packers vs. Cowboys (+6.5)

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