Norway: Exposure to statins during the first trimester of pregnancy does not appear to increase the risk of congenital malformations , according to a large nationwide study from Norway published in the European Heart Journal . The findings provide reassuring evidence for women who require lipid-lowering therapy and suggest that previous concerns based on animal studies may overestimate the risk in human pregnancies.

The study, led by Jacob J. Christensen and colleagues from the University of Oslo, leveraged national registry data encompassing more than 800,000 pregnancies between 2005 and 2018. Researchers categorized pregnancies as statin-exposed if a prescription was filled during the first trimester, previously exposed if a prescription was filled in the year before pregnan

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