Last season, there were five games with NFL spreads of at least two touchdowns, and all five games took place in December. Thus, Buffalo being a 15.5-point favorite over New Orleans, per the Week 4 NFL odds, comes at an interesting time, but it says lots about both teams. The Saints are one of three winless teams against the spread, along with Denver and Houston. Despite that, the Week 4 NFL lines have both the Broncos and Texans as touchdown favorites in their respective games as there are four Week 4 NFL spreads of 7 points or more.

A Week 4 NFL betting guide would help navigate the final slate of games before the byes hit and also help identify the top players to target for NFL props, Week 4 Fantasy football lineups and as NFL DFS picks. Will players like Josh Allen, James Cook, Bo Nix

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