Sep 20, 2025; Greenville, North Carolina, USA; Brigham Young Cougars quarterback Bear Bachmeier (47) runs for a touchdown against the East Carolina Pirates during the second half at Dowdy-Ficklen Stadium. Mandatory Credit: James Guillory-Imagn Images

Week 5 doesn't end with the evening slights. The Big 12 has gifted the nation a nightcap out in Colorado when the BYU Cougars head to Folsom Field in Boulder, Colorado, to take on the Colorado Buffaloes and Deion Sanders.

BYU enters this matchup undefeated, but without any being tested, having beaten Portland State, Stanford, and East Carolina. The Buffaloes have alternated wins and losses this year, starting with a loss to Georgia Tech, a win over Delaware, a loss to Houston, and then a win over Wyoming last weekend.

If you are looking for some betting advice for the matchup, we've got you covered. Here are the latest odds for the game, courtesy of BetMGM.

Stream BYU vs. Colorado

BYU vs. Colorado game odds

All college football odds via BetMGM

  • Spread: BYU -6.5 (-110), Colorado +6.5 (-110)
  • Money Line: BYU -250, Colorado +200
  • Over-Under: Over 49.5 (-110), Under 49.5 (-110)

BYU vs. Colorado prediction, pick:

Colorado has the luxury of this game being at home, and Folsom Field figures to be charged up when this game kicks off under the beautiful night sky by the mountains.

That may be where the luxuries end. BYU has arguably the best-named quarterback in the country, Bear Bachmeier, who sports No. 47. IF that isn't good enough, he is completing 66.7% of his passes, has yet to throw an interception, and has four rushing touchdowns.

Colorado has beaten two Group of Five schools and lost to both Power Four programs they have played. No need to overthink this one. BYU gets the better of the Buffaloes Saturday night.

Prediction: BYU 30, Colorado 20

Best Bet: BYU -6.5

BYU vs. Colorado channel, start time, streaming:

Time: 10:15 p.m. ET

TV Channel: ESPN

Live Stream: ESPN App

Get more betting analysis and predictions at Sportsbook Wire.

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This article originally appeared on College Sports Wire: BYU vs. Colorado: Week 5 College Football Betting Odds, Prediction, Pick

Reporting by Riley Donald, College Sports Wire / College Sports Wire

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