Sunday’s Week 4 slate features a lopsided AFC–NFC matchup as the undefeated Buffalo Bills host the winless New Orleans Saints. Buffalo has stormed out to a 3-0 start with a +31 point differential, while New Orleans enters at 0-3 and struggling with a -43 margin. Oddsmakers have the Bills pegged as double-digit favorites at home , and Bet365 is adding extra intrigue with a series of exclusive Bet Boost parlays.

These boosted odds highlight the stars most likely to shape the outcome, from Josh Allen’s dual-threat production to James Cook’s ground game and the Saints’ top playmakers like Alvin Kamara and Chris Olave, giving bettors creative ways to back their picks in a game where Buffalo is expected to control the action.

New NFL Week 4 odds boosts for Josh Allen, James Cook, and more

B

See Full Page