The New Orleans Saints (0-3) visit the Buffalo Bills (3-0) Sunday at Highmark Stadium in Orchard Park, New York. Kickoff is scheduled for 1 p.m. ET (CBS). Let's analyze BetMGM Sportsbook's NFL odds around the Saints vs. Bills odds and make our expert NFL picks and predictions for the best bets.

New Orleans has yet to find the win column after losing its third straight game last week in a 44-13 loss against the Seattle Seahawks while failing to cover as a 7.5-point road underdog. QB Spencer Rattler went 28 of 39 for 218 yards with a touchdown and an interception while the Saints had just 79 rushing yards in the losing effort.

Buffalo remains undefeated after taking care of the Miami Dolphins last Thursday with a 31-21 win while narrowly failing to cover as an 11-point home favorite. QB Josh Allen went 22 of 28 for 213 yards and 3 TDs, with TE Dalton Kincaid (5 receptions, 66 yards, 1 TD) being his top target. On the ground, RB James Cook carried the ball 19 times for 108 yards and a TD.

The last time the Saints and Bills faced off was Nov. 2021, with the Bills dominating the Saints 31-6, covering as 6.5-point road favorites and the Under of 45 hitting.

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Saints at Bills odds

Provided by BetMGM Sportsbook; access USA TODAY Sports Scores and Sports Betting Odds hub for a full list. Lines last updated Saturday at 3 p.m. ET.

  • Moneyline (ML): Saints +1000 (bet $100 to win $1,000) | Bills -2000 (bet $2,000 to win $100)
  • Against the spread (ATS): Saints +15.5 (-110) | Bills -15.5 (-110)
  • Over/Under (O/U): 48 (O: -110 | U: -110)

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Saints at Bills key injuries

Saints

  • G Dillon Radunz (toe) out
  • WR Devaughn Vele (hip) questionable
  • DE Chase Young (calf) out

Bills

  • T Spencer Brown (calf) questionable
  • DE A.J. Epenesa (pectoral) questionable
  • LB Matt Milano (pectoral) out
  • DT Ed Oliver (ankle) out

Saints at Bills picks and predictions

Prediction

Bills 31, Saints 10

Moneyline

PASS.

There is no value on the undefeated Bills (-2000) to handle the winless Saints Sunday.

Against the spread

LEAN BILLS -15.5 (-110).

This spread is the largest in any matchup this week by 5.5 points, but the Bills are more than capable of covering, even dealing with injuries to their defense. They are 2-1 ATS this season and have won their previous 2 games by 30 points combined. Their offense has been dominant this season, scoring 30 or more points in each of their 3 games.

The Saints have looked like one of the NFL's worst teams this season, failing to cover in each of their 3 games while scoring 13 points in 2 of their 3 games. They were dominated by 31 points last week in their first road game and could be in for another beating in a tough Buffalo atmosphere.

Over/Under

BET UNDER 48 (-110).

The Bills will account for a majority of the points, but with the inadequacy of the Saints' offense, it will not be enough. The Bills have scored 31 points or fewer in their last 2 games while allowing 21 points or fewer in that span.

As it stands, this will be the highest total of the Saints' season. They have scored 13 points in 2 of their 3 games while allowing 26 or fewer points in 2 of their 3 games.

In what is expected to be a one-sided affair, the Saints will be the reason for the Under hitting.

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This article originally appeared on Sportsbook Wire: New Orleans Saints at Buffalo Bills odds, picks and predictions

Reporting by Seth Orlemann, Sportsbook Wire / Sportsbook Wire

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