The Colorado Buffaloes (2-2) welcome the No. 25 BYU Cougars (3-0) to Folsom Field on Saturday for a Big 12 clash. Colorado enters the matchup riding the momentum of a 37-20 victory over Wyoming on Sept. 20, a game that saw Liberty transfer Kaidon Salter step in at quarterback and deliver a strong performance for head coach Deion Sanders. Meanwhile, BYU remains unbeaten, winning its first three contests by an average margin of 38 points, including a 34-13 victory over ECU in its most recent outing. These teams met in the 2024 Valero Alamo Bowl, with BYU winning 36-14. Colorado is 2-2 and BYU is 3-0 against the spread in 2025.

Kickoff is set for 10:15 p.m. ET at Folsom Field in Boulder. The Cougars are 6.5-point favorites in the latest Colorado vs. BYU odds, while the over/under for total p

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