The Indianapolis Colts try to extend their undefeated start against the Los Angeles Rams at 4:05 p.m. ET

The Indianapolis Colts try to remain unbeaten when they visit the Los Angeles Rams in NFL Week 4 action. Three Colts starters are out with injuries, and the Rams are watching the availability of wide receiver Davante Adams (hamstring).

The Colts have won two blowouts and with a walk-off field goal. The Rams beat two AFC South teams before squandering a 19-point lead against the Eagles in Philadelphia.

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What time does Los Angeles Rams-Indianapolis Colts game start today, Sunday, Sept. 28, 2025? When is Colts-Rams NFL football game tonight?

The Indianapolis Colts and Los Angeles Ram

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