The San Francisco 49ers will try to stay undefeated when they host the Jacksonville Jaguars in a Week 4 NFL battle. The 49ers (3-0) survived an ugly 16-15 win against the Arizona Cardinals in Week 3, but added to their laundry list of injuries. However, San Francisco's starting quarterback Brock Purdy is expected to return to the starting lineup on Sunday. The 49ers welcome a Jaguars team (2-1) coming off a 17-10 victory against the Houston Texans.

Kickoff from Levi's Stadium is set for 4:05 p.m. ET. San Francisco is a 3.5-point favorite in the latest Jaguars vs. 49ers odds from SportsLine consensus, while the over/under for total points scored is 46.5. The 49ers are -181 money line favorites (risk $181 to win $100), while the Jaguars are +149 underdogs. Before making any 49ers vs. Ja

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