Leucovorin May Have Promise In Autism, But Science Is Far From Settled

Washington DC - On Monday, Sept. 22, 2025, President Donald Trump said his administration was linking acetaminophen, the active ingredient in Tylenol, to autism and urging pregnant women to largely avoid the medication. At the same time, the Food and Drug Administration is approving use of leucovorin for autism. Photographer: Francis Chung/Politico/Bloomberg © 2025 Bloomberg Finance LP

The Trump administration announced late last month "bold actions to tackle the autism epidemic.” President Trump said there was a possible link between acetaminophen, the active ingredient in Tylenol, and autism. Controversially, he urged pregnant women to largely avoid the medication. At the same time, the Food and Drug Administration announced it is approving use of leucovorin (folinic acid) calcium t