Injuries just won’t leave the 49ers alone.

San Francisco quarterback Brock Purdy will miss Thursday night’s game against the Rams with a toe injury, giving Mac Jones his third start of the season, ESPN’s Adam Schefter reported Wednesday .

It will be Purdy’s third absence through five weeks after he suffered a shoulder and toe injury during Week 1 and missed the subsequent two games.

Brock Purdy #13 of the San Francisco 49ers throws a pass against the Jacksonville Jaguars during the third quarter at Levi’s Stadium on September 28, 2025 in Santa Clara, California. Getty Images

And that’s not all.

The 49ers will also be without starting wide receivers Ricky Pearsall (knee) and Jauan Jennings (ankle, ribs).

San Francisco was already without star tight end George Kittle , who is on i

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