San Francisco 49ers running back Christian McCaffrey (23) carries the ball against the Jacksonville Jaguars during the second quarter at Levi's Stadium in Santa Clara, California.

The San Francisco 49ers (3-1) and LA Rams (3-1) meet Thursday night to open Week 5. Kickoff from SoFi Stadium in Inglewood, California, is set for 8:15 p.m. ET (Prime Video). Let's analyze BetMGM Sportsbook's 49ers vs. Rams odds and tab the 5 best prop bets to win among SportsbookWire's expert NFL picks and predictions for Week 1.

The Rams bounced back from their Week 3 loss at the Philadelphia Eagles with a 27-20 home win over the Indianapolis Colts in Week 4. QB Matthew Stafford threw for 375 yards and 3 touchdowns, while WR Puka Nacua caught 13 passes for 170 yards and a score to earn Player of the Week honors.

The 49ers dropped their first game of the season in Week 4, a 26-21 home loss to the Jacksonville Jaguars. QB Brock Purdy threw 2 touchdown passes but was intercepted twice and lost a fumble.

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Best 49ers at Rams prop bets

Odds provided by BetMGM Sportsbook; access USA TODAY Sports Scores and Sports Betting Odds hub for a full list. Lines last updated Wednesday at 7:40 p.m. ET.

49ers RB Christian McCaffrey OVER 63.5 RUSHING YARDS (-115)

The Rams are a tough defense, but McCaffrey is the 49ers' only offense right now. He hasn't surpassed 63 rushing yards since Week 1, but with injuries all over the offense, you have to ride McCaffrey.

Better options would be receiving props or alternate rushing + receiving yards, but those are not on the board currently.

Rams RB Kyren Williams OVER 67.5 RUSHING YARDS (-115)

The 49ers are allowing 4.0 yards per rushing attempt this season. Williams has rushed for 77 or more yards in each of his last 2 games. If he gets his average of 17 carries and the 49ers give up 4.0 yards per rush, he’ll finish with 68.

  • 49ers at Rams: Odds, picks and predictions

RAMS QB Matthew Stafford OVER 0.5 INTERCEPTIONS THROWN (+110)

Stafford has thrown 2 interceptions this season, each in a different game. The 49ers haven’t forced a turnover in their last 2 contests. He threw 2 interceptions against San Francisco in 2023 but went turnover-free against it last season.

With plus odds for a pick, it's worth taking.

Rams WR Puka Nacua OVER 97.5 RECEIVING YARDS (-110)

Nacua is coming off a 170-yard performance. He has cleared 110 yards in 3 of 4 games this season.

49ers WR Demarcus Robinson ANYTIME TD (+320)

The 49ers ruled out WRs Jauan Jennings and Ricky Pearsall, leaving Robinson and Kendrick Bourne as the top 2 receiving targets. This anytime TD offers good value.

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This article originally appeared on Sportsbook Wire: San Francisco 49ers at LA Rams best prop bets for Thursday Night Football

Reporting by Jess Root, Sportsbook Wire / Sportsbook Wire

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