The head of Washington University, one of the largest employers in the St. Louis area, announced the school is cutting more than 300 jobs as shake-ups in higher education and potential cuts to federal funding affect its budget.

Chancellor Andrew D. Martin, in a letter addressed to faculty and staff on Tuesday , wrote that the university is eliminating 316 staff positions and closing 198 vacant positions, which he said will result in $52 million in annual savings.

The job cuts are spread across the school’s main and medical campuses and its central fiscal unit, which comprises financial and other nonacademic offices.

“If we want to be great, and not just good, we must focus our resources where they will have the most impact and ensure that we’re positioned for success in the long-ter

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