The San Francisco 49ers travel to Los Angeles on Thursday night hoping an injury-riddled offense can hold up against the Rams' ninth-ranked defense.

Los Angeles has produced 14 sacks and 20 tackles for loss through its 3-1 start. San Francisco also enters 3-1, but will turn to backup Mac Jones for a crucial NFC West matchup with quarterback Brock Purdy sidelined by his nagging turf toe injury.

ODDS AND TRENDS

The 49ers' offense will also be without wide receivers Jauan Jennings (ankle), Ricky Pearsall (knee) and Jordan Watkins (calf), with Brandon Aiyuk and tight end George Kittle already on injured reserve. That has led to the Rams being a consensus 9.0-point favorite as of Thursday afternoon.

The line is 8.5 points at BetRivers, where 79 percent of the spread-line money is backing Lo

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