Teams looking to get into the win column in Big 12 play meet when the Colorado Buffaloes take on the TCU Horned Frogs on Saturday. Colorado is coming off a 24-21 loss to BYU, while TCU fell 27-24 at Arizona State in Week 5. The Buffaloes (2-3, 0-2 Big 12), who have lost two of three, are 0-1 on the road this season. The Horned Frogs (3-1, 0-1 Big 12), who are looking to avoid a 0-2 start to conference play for the first time since 2013, are 2-0 on their home field in 2025.

Kickoff from Amon G. Carter Stadium in Fort Worth, Texas, is at 7:30 p.m. ET. The all-time series is tied 1-1. The Horned Frogs are 13.5-point favorites in the latest Colorado vs. TCU odds, while the over/under for total points scored is 57.5 via SportsLine consensus. Before making any Colorado vs. TCU picks, chec

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