The South Florida Bulls open AAC play when they take on the Charlotte 49ers on Friday night. Charlotte is coming off a 28-17 loss to Rice on Sept. 18, while USF cruised to a 63-14 win over South Carolina State on Sept. 20. The 49ers (1-3, 0-1 American), who were 5-7 overall in 2024, will be playing their first true road game of the year. The Bulls (3-1, 0-0 American), who are 1-0 against unranked opponents, are 2-0 on their home field.

Kickoff from Raymond James Stadium in Tampa, Fla., is at 7 p.m. ET. South Florida leads the all-time series 2-0, including a 59-24 win last season at Charlotte. The Bulls are 28-point favorites in the latest South Florida vs. Charlotte odds, while the over/under for total points scored is 54.5 via SportsLine consensus. Before making any Charlotte vs. So

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