UNC football and Clemson will play in Chapel Hill for just the third time in the last 15 years on Saturday, Oct. 4 (Noon, ESPN) at Kenan Stadium.

The Tar Heels (2-2) and Tigers (1-3, 0-2 ACC) are led by coaching legends in Bill Belichick and Dabo Swinney, but neither team has beaten a Power 4 team through five weeks in the 2025 season. Despite its struggles after starting the season as a top-five team, Clemson is a 14-point favorite against UNC, according to BetMGM.

Oddsmakers are projecting a low-scoring game with the total points set at 46 ½ points. The Tigers are 0-4 against the spread this season and the Heels are 0-2 against the spread in its two games against Power 4 competition.

Here are predictions, picks and betting odds for UNC vs. Clemson.

UNC vs Clemson odds, money line, ov

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