Sep 20, 2025; Orlando, Florida, USA; North Carolina Tar Heels running back Demon June (35) catches a pass during the second half against the UCF Knights at the Bounce House Stadium. Mandatory Credit: Mike Watters-Imagn Images

Clemson hits the road on Saturday to take on North Carolina in an ACC battle. Both of these teams are looking for their first conference win of the season.

The Tigers are the more desperate team, as they already have two losses in conference play. They have not looked good in losses to Georgia Tech and Syracuse. They need something good to happen and a date with the Tar Heels might be exactly what they need.

The Tar Heels, though, are hoping to continue the Tigers' struggles. The Tar Heels have two wins on the year, but they came against Richmond and Charlotte. They are 0-2 against Power Four teams, and they lost those games by a combined 59 points.

Stream North Carolina vs. Clemson

If you're looking to get back in the swing of football season and need some betting advice for Saturday's matchup in Chapel Hill, we've got you covered. Here are the latest odds for the game, courtesy of BetMGM.

UNC vs. Clemson game odds:

All college football odds via BetMGM

  • Spread: Clemson -14 (-110), North Carolina +14 (-110)
  • Money Line: Clemson -600, North Carolina +425
  • Over-Under: Over 46.5 (-115), Under 46.5 (-110)

UNC vs. Clemson prediction, pick:

This is a game of two teams that have struggled this season. Clemson was supposed to have a great offense and the Tar Heels were supposed to take a step up with Bill Belichick in charge. Neither has happened. The Tar Heels, though, have looked worse, but do the Tigers have enough to blow them out? We think they will finally break out against a bad Tar Heels team. The Tigers cover, but barely.

Prediction: Clemson 27, North Carolina 10

Best Bet: Clemson -14, Under 46.5

UNC vs. Clemson channel, start time, streaming:

Time: 12 p.m. ET

TV Channel: ESPN

Live Stream: ESPN App

Get more betting analysis and predictions at Sportsbook Wire.

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This article originally appeared on College Sports Wire: UNC vs. Clemson: Week 6 College Football Betting Odds, Prediction, Pick

Reporting by Adam Childs, College Sports Wire / College Sports Wire

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