Andy's running back start 'em, sit 'em picks for fantasy football Week 5 lineups (2025). Read his expert RB start/sit advice for Michael Carter, Alvin Kamara, Chase Brown, others.

The running back position has been hit hard by injuries over the past two weeks. In Week 3, managers watched as James Conner (foot) and Najee Harris (Achilles) suffered season-ending injuries. Earlier this week, Trey Benson (knee) hit the IR, and Bucky Irving (foot) is in danger of not only missing Week 5 but potentially longer.

As a result, we may have to look deeper to find optimal plays.

In this weekly piece, we don't look at those must-start options because if you have them, you start them. Instead, we look at those low-range RB2/flex options that are on the verge of start territory. Let's take a l

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