Week 5 of the NFL season kicks off in Indianapolis with the Colts hosting the Las Vegas Raiders at Lucas Oil Stadium. Set for a 1 p.m. ET kickoff on Sunday, this matchup features two teams trending in different directions as the season begins to take shape. The Colts, led by Daniel Jones and star running back Jonathan Taylor, are looking to defend home turf and keep momentum in the AFC South race. The Raiders, meanwhile, travel east hoping Geno Smith and rookie running back Ashton Jeanty can help pull off an upset against a well-balanced Indianapolis squad.

According to the latest odds, the Colts enter as 7-point favorites (-102) with a -325 moneyline, while the Raiders sit at +270 to win outright. The total is set at 47.5 points, suggesting the potential for an entertaining, moderately

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