The New England Patriots will try to make it two straight wins when they trek to Western New York for a date with the Buffalo Bills on Sunday night.

The Pats (2-2) thumped the Carolina Panthers 42-13 on Sunday behind a huge day from Drake Maye. The second-year QB went 14 for 17 for 203 passing yards and wo touchdowns plus three rushes for 11 yards and a TD too.

But to get above .500, the Pats will need to defeat the Bills at Highmark Stadium — something that has not been done since the 2024 AFC Championship Game.

Here’s a look at the Bills vs Patriots odds and best bets to make at the best Massachusetts sportsbooks .

Patriots vs Bills predictions and best bets

Patriots +8.5 (-112) at FanDuel

Over 49 points (-110) at Fanatics

Drake Maye Over 27.5 Rushing yards (-114) at FanDuel

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